VEGFR2 KISE INHIBITOR I
SU5408
CAS: 15966-93-5
Molecular Formula: C18H18N2O3
VEGFR2 KISE INHIBITOR I - Names and Identifiers
VEGFR2 KISE INHIBITOR I - Physico-chemical Properties
| Molecular Formula | C18H18N2O3 |
| Molar Mass | 310.35 |
| Density | 1.271±0.06 g/cm3(Predicted) |
| Boling Point | 571.4±50.0 °C(Predicted) |
| Solubility | DMSO: 6 mg/mL |
| pKa | 12.40±0.20(Predicted) |
| Storage Condition | Sealed in dry,Store in freezer, under -20°C |
| In vitro study | 3-Substituted indolin-2-ones have been designed and synthesized as a novel class of tyrosine kinase inhibitors which exhibit selectivity toward different receptor tyrosine kinases (RTKs). These compounds have been evaluated for their relative inhibitory properties against a panel of RTKs in intact cells. SU5408 (VEGFR2 Kinase Inhibitor I) is found to be the most potent and selective VEGFR2 inhibitor among the compounds. SU5408 (VEGFR2 Kinase Inhibitor I) shows little or no effect against receptors for platelet-derived growth factor, epidermal growth factor, or insulin-like growth factor (IC 50 >100 µM). |
VEGFR2 KISE INHIBITOR I - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.222 ml | 16.111 ml | 32.222 ml |
| 5 mM | 0.644 ml | 3.222 ml | 6.444 ml |
| 10 mM | 0.322 ml | 1.611 ml | 3.222 ml |
| 5 mM | 0.064 ml | 0.322 ml | 0.644 ml |
Last Update：2024-01-02 23:10:35
VEGFR2 KISE INHIBITOR I - Reference Information
| biological activity | SU5408 (VEGFR2 Kinase Inhibitor I) is a potent and selective Inhibitor of VEGFR2 Kinase, the IC50 was 70 nM. |
| Target | Value |
| VEGFR2 (Cell-free assay) | 70 nM |
Last Update：2024-04-09 21:54:55
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Spot supply
Product Name: SU5408 Visit Supplier Webpage Request for quotationCAS: 15966-93-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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